Influence of pH on the release of a once daily formulation of ciprofloxacin tablets prepared with different polymers

Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media pH. Methods: Different formulations slow-release matrix tablets were polymers, namely, ethyl cellulose (Etc), hydroxyethyl (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using embedding technique. The characterized studies their profiles studied 0.1 N HCl (pH 1.2) simulated intestinal fluid (excluding enzymes) pH 4.0, 6.0, 7.4. Results: had following characteristics: weight, 659.25 ± 7.96 to 661.65 6.53 mg; hardness, 7.05 0.21 9.60 0.40 kgf; friability, 0.212 0.292 %; drug content, 91.47 0.53 112.50 4.14 %. In batches cellulose, Eudragit L-100, methylcellulose, increased a decrease However, displayed highest at 4.0 Cmax 108.75 % T50% 30.86 min; thereafter, decreased increase pattern was Hec > Hpc Eud Etc most more acidic than alkaline Conclusion: Release from formulated pH-sensitive vitro. This should be taken into consideration designing sustained oral form ciprofloxacin.